Home of the MESE® Computing System

What is MESE®

MESE® is a computing system that provides unique insights into businesses that disclose little or no public data about their financial or commercial status. Since 2008 it has helped executives guide billions of dollars in venture capital, innovation, acquisitions and related growth initiatives.

For example, it can:

  • Identify which startups are winning or losing globally, at any time; and

  • Predict if businesses will survive or fail with unprecedented accuracy. 

What is Growth Science?


Growth Science manages R&D collaborations between WR Hambrecht+Co and an elite group of global companies that contribute to MESE's®  development while benefiting from its capabilities on an ongoing basis. 

By partnering with leading firms in thematically targeted industries, MESE® continually evolves with one of the largest and richest proprietary databases of corporate innovation and growth efforts in the world.

This lets businesses better identify growth opportunities, predict market outcomes and adjust to hit their goals.  

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8X more accurate predicting new business survival than a multi-billion dollar technology company



Growth Science was founded by data scientist and venture capitalist Thomas Thurston, Chief Technology Officer of WR Hambrecht+Co.


More than a decade ago Thurston started using data science to guide growth investments at Intel. These methodologies were further developed by Thurston and Professor Clayton Christensen through joint R&D between Intel and the Harvard Business School.

Thurston then teamed up with renowned investor William Hambrecht. The result was MESE® , an advanced computing system that has been custom built to deliver unique venture capital, innovation, M&A and strategic commercial insights. 

Led by Thurston and Cristin Moran Ph.D., Growth Science facilitates select R&D collaborations with industry-leading firms each year. This allows MESE®  to constantly evolve while amassing one of the largest known databases of corporate growth initiatives. Corporate applications to collaborate with Growth Science are evaluated case by case and membership is strictly limited.

“This is something people will look back on as the first tool to introduce data-driven management.”


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